GLUTAMINE – OUR MOST IMPORTANT AMINO ACID ALTHOUGH ITS NON-ESSENTIAL
Glutamine is our most abundant amino acid representing approx. 40-60% of our total amino acid pool! Glutamine dominates our blood and tissues and has so many positive functions that this post will not even get close to covering. I will go through the most important processes glutamine is involved in.
GLUTAMINE AND THE GUT
Glutamine is able to be used as an intermediate in the krebs cycle to make ATP energy available to many cells. In the enterocytes of the small intestines 75% of the energy production comes from glutamine (Labow et al. 2001). Phosphate-dependent glutaminase (GLS) is an enzyme with a high affinity for glutamine. Almost all GLS is bound to mitochondrial membrane in intestinal cells. This is highly important to maintain tissue integrity, enable adequate absorption of nutrient and prevent bacteria from translocating into the blood stream (septicaemia) (Kim & Kim, 2017).
Glutamine plays a role in mediating the activation of mammalian target of rapamycin (mTOR) which is essential for tissue size and mass regulator. The use of amino acids, mainly leucine, as anabolic inducers in muscle cells has its action on mTOR compromised when glutamine is not available (Tan et al. 2017). Glutamine is protective to resistance response injuries from its antioxidant and cytoprotective effects as it modulates the expression of heat shock proteins. Furthermore, glutamate from glutamine is an essential substrate for the synthesis of glutathione, our master antioxidant (Cruzat et al. 2014).
Glutamine is crucial for energy metabolism and proliferation of hepatocytes in the liver. It acts a important precursor for making glucose and allows blood sugar levels to maintain a satisfactory level. It’s a key amino acid involved in nitrogen metabolism which consequently regulates the blood pH and detoxification of Ammonia via the urea cycle using glutamine (Haussinger & Schliess, 2007).
During an infection or high catabolism, the immune cells such as macrophages, neutrophils and lymphocytes use glutamine in similar or greater levels than glucose (Newsholme et al. 1987). During these states of infection or catabolism, glutamine concentrations are decreased because of its demand and must synthesise glutamine via the skeletal muscles causing more catabolism but with the benefit of preventing disease (Oudemans-van Straaten et al. 2001).
WHY YOU SHOULD TAKE IT
Its very clear in the literature of how helpful glutamine is when in a catabolic state. By supplementing with glutamine it appears to reduce catabolism which helps to maintain lean muscle mass which is crucial when trying to lose weight. Not only that, it regulates mTOR activity and it may even increase mTOR along with leucine which no studies have been done yet which I would love to see. The impact glutamine has on the health state of your intestinal cells is significant as it’s the primary substrate for energy production, DNA and RNA synthesis via being a precursor for pyrimidine’s and purine’s. Furthermore, your immune system relies heavily on glutamine to fight infections. I have barely touched the sides with this information guys, there is honestly too much. I invite you to research glutamine yourself and find out how much it really does support the body. This supplement is a must in my book and I would highly recommend its use when trying to lose weight.
I cannot recommend or speak highly enough of Tim and his team at Bodyseek Personal Training, they are quite literally beyond compare!
Tim's knowledge and execution of training, nutrition, and supplement programs to suit a person’s age, background and lifestyle, and secure amazing results, is brilliant.
As is the case with anything somewhat difficult to attain, a fair amount of grit and determination are required from yourself as an individual, but to have the support of Tim and his team maximises every minute spent in the gym, every meal decision made, and ensures profound results..
Sick of all the advice so called 'people in the know' bang on about yet leaves you without a result? Give the guys at Bodyseek Personal Training a call and see what makes them so different.
Have never been fitter, healthier, or happier in my life as I am now, and I am well into my fifties..
TeamMates / TMA ClubJan 2023
I have been attending Bodyseek for 6 months. The gym has excellent equipment and is very clean and well maintained. I have been training with Lucas since joining and I have benefited from his rehabilitation knowledge and training expertise in that time. I arrived with a number of issues with my knees and walked with a limp and was in varying degrees of pain most days. Lucas has built a progressive training plan for me focusing on building the strength stability and mobility of my knees and overall body strength and we have achieved great results. My mobility and movement have improved noticeably. I look forward to continuing my journey with the Bodyseek team.
Jacqui VDec 2022
Personal training with Lucas is as elite as it can get. You’re provided with knowledge about the specifics of what you’re training to prevent injury, gain strength and nutrition on your wellness journey. Definitely moneys worth.
Helen PanayiNov 2022
Awesome place to train great facilities and coaches Lucas Lim is an amazing coach very professional.
Stephen MorrisNov 2022
Chris is a wonderful coach he always pushes me to do better. The whole team have become like family a great fun and supportive environment to work towards your fitness goals.
Ange SNov 2022
If you want to change your life around through wellness one can't look past Chris and Bodyseek. I could write in detail how great the work and ability for transformation to positively effect all facets of one's life but I can't recommend Chris and the work from Bodyseek enough so I'm encouraging anyone reading this review to try them and see it for yourself. It's no run of the mill gym or programme. The service here is completely personal where you're made to feel a part of the team and the results can be incredible if you're willing to put the work in.
Chochy KileenNov 2022
Joining BodySeek almost six months ago is one of the best decisions I've made this year. BodySeek provides a highly personalised and professional personal training service.
I had never stepped foot in a gym prior to BodySeek and so was somewhat apprehensive and unsure of what to expect. However, the process to date has been seamless and transformational for my physical and mental health. Joining is easy and the gym is well-equipped, private and low pressure (but high intensity!).
My trainer, Kevin, is a legend. He's fantastic at inducting new people to the gym and made an amateur like me feel completely comfortable learning and growing throughout the initial 12-week programme. I also did one session with Jack when Kevin was away and he was also excellent and insightful - the amount you can learn from these guys is immense! I have ended up staying on as I've enjoyed it so much. I've made great progress and I'm looking forward to continuing!
Nic PopeOct 2022
Both Kevin and Tim (the owner), are invested in your progress and success. I've found them to be available and highly knowledgeable and have learnt a lot about technique, physical fitness and nutrition.
Tim has a real focus on excellence and ensuring that BodySeek delivers a best-in-class training service. If you're looking for a personalised PT & gym I recommend giving them a go!
Nic PopeOct 2022
Best decision to join Bodyseek six months ago!! Very professional group of trainers. I was so apprehensive about getting a PT for years… but Kevin is an absolute legend, he’s helped me get through the initial challenges and to a stage where I actually quite like training and want to do even better (and so I have added an extra session!) Tim the owner is super knowledgeable and will help you stay on track and supported with any overall life and nutrition changes needed so that you can achieve something sustainable 🙂
Alison ClarkeOct 2022
I am so glad that I chose Bodyseek when I was looking for help to strengthen my bad back, lose some weight and sort out my bad eating and drinking habits.
I had never had a personal trainer before, but I believe it's worth the money for the attention that you get.
My trainer Kevin has pushed me way beyond any limit that I thought I could do, while teaching me good technique to avoid injury.
Tim is fantastic with sorting out nutrition and is incredibly knowledgeable with supporting any health issues.
I have enjoyed it so much that I have just completed my 12 week block and have stayed on for another round. That says a lot because I'm not a 'gym person'.
I'm loving how strong I am becoming and my over 50's body is going to look awesome this summer!
Cyndi BriggsOct 2022
1 train 3 days a week with Dasha l love how she challenges me to do better and because of her help l am keeping up my Flexibility and mobility which is so important as you get older without my training l would struggle day to day.